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Nalc article 3
Nalc article 3





Erhöhte FGF21-Spiegel verringern den schädlichen Alkoholkonsum bei Mäusen. FGF21 reguliert neben vielen anderen Prozessen die Aufnahme von einfachem Zucker und Alkohol. Further research is required to clarify these pathologies, which may open new pharmacological treatment for patients with alcohol use disorder and alcohol dependence.įibroblast-Growth-Factor 21 (FGF21) wird in der Leber produziert und bindet an verschiedene komplexe Rezeptor/Corezeptor-Systeme.

nalc article 3

That points towards a pathology in this pathway, which might be caused by a malfunction of β‑Klotho or FGF receptors according to other studies and chronic alcohol dependency. We could not confirm that elevated FGF21 levels were associated with reduced alcohol intake as a result. Increased FGF21 levels in patients with recent alcohol consumption (verified by ETG) confirmed the first part of the liver–brain endocrine axis: alcohol consumption was associated with increased FGF21 levels. Eating behaviour did not have an impact on FGF21 plasma levels. Resultsīoth ALC and NALC patients with elevated ETG levels (≥0.5 μg/ml indicating alcohol consumption in the last 12–72 h) showed significantly higher FGF21 plasma levels in comparison to patients with negative ETG levels.

nalc article 3

MethodsĪlcohol intake was verified by urinary ethyl glucuronide (uETG) levels, eating and drinking behaviour by a Food Frequency Questionnaire and FGF 21 plasma levels were determined by ELISA in 96 persons (ALC n = 41 NALC n = 34 healthy n = 21).

nalc article 3

To increase our understanding on the relationship between FGF21 and alcohol intake in humans, we aimed to measure FGF21 levels in patients with alcoholic liver cirrhosis (ALC) in comparison to patients with nonalcoholic liver cirrhosis (NALC) and healthy persons based on their present alcohol consumption.

nalc article 3

Increased levels of FGF21 decrease harmful alcohol intake in mice. Besides many other processes, FGF21 regulates the intake of simple sugars and alcohol. Fibroblast growth factor 21 (FGF21) is produced in the liver and binds to different complex receptor/coreceptor systems.







Nalc article 3